Modern NMR Techniques for Chemistry research

From A.E. Derome, Modern NMR Techniques for Chemistry research (1987):

“Modern pulse NMR is performed exclusively in the Fourier transform mode. Of course it is useful to appreciate the advantages of the transform, and particularly the spectacular results which can be achieved by applying it in more than one dimension, but it is also essential to understand the limitations imposed by digital signal analysis. The sampling of signals, and their manipulation by computer, often limit the accuracy of various measurements of frequency and amplitude, and may even prevent the detection of signals altogether in certain cases. These are not difficult matters to understand, but they often seem rather abstract to newcomers to FT-NMR. Even if you do not intend to operate a spectrometer, it is irresponsible not to acquire some familiarity with the interaction between parameters such acquisition time and resolution, or repetition rate, relaxation times and signal intensity. Many errors in the use of modern NMR arise because of a lack of understanding of its limitations.”

 

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